Related Experiment Video

Updated: Aug 8, 2025

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients
08:37

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Published on: April 18, 2025

381

SAGE Score in Normotensive and Pre-Hypertensive Patients: A Proof of Concept

Rayne Ramos Fagundes Rigonatto1,2, Priscila Valverde Oliveira Vitorino1,2,3, Adriana Camargo Oliveira1

  • 1Universidade Federal de Goiás - Programa de Pós-graduação em Ciências da Saúde, Goiânia, GO - Brasil.

Arquivos Brasileiros De Cardiologia
|March 1, 2023
PubMed

Insights

The SAGE score effectively identifies individuals at risk for increased pulse wave velocity (PWV), even in non-hypertensive and pre-hypertensive groups. Further refinement is needed for a specific score tailored to these populations.

Area of Science:

  • Cardiovascular Physiology
  • Biomedical Engineering
  • Clinical Diagnostics

Background:

  • The SAGE score was initially developed to identify individuals at risk for elevated pulse wave velocity (PWV).
  • Previous research primarily focused on the application of the SAGE score within hypertensive patient populations.

Purpose of the Study:

  • To evaluate the SAGE score's efficacy in detecting increased PWV among non-hypertensive and pre-hypertensive individuals.
  • To assess the score's ability to identify early signs of arterial stiffness in at-risk, non-hypertensive populations.

Main Methods:

  • A retrospective cross-sectional study analyzed central blood pressure data and calculated SAGE scores in 100 normotensive and pre-hypertensive subjects.
  • Sensitivity, specificity, and predictive values were determined for various PWV cut-off points (≥10 m/s, ≥9.08 m/s, ≥7.30 m/s).
  • Statistical significance was set at p<0.05.

Main Results:

  • The SAGE score demonstrated strong correlations with age (r=0.938), glycemia (r=0.366), and glomerular filtration rate (r=-0.658).
  • Areas under the ROC curve were high across all PWV cut-offs (0.967-0.977), indicating excellent diagnostic performance.
  • Optimal cut-off points were identified: score 7 for PWV ≥10 m/s (95.40% specificity, 100% sensitivity), score 5 for PWV ≥9.08 m/s (96.00% sensitivity, 94.70% specificity), and score 2 for PWV ≥7.30 m/s.

Conclusions:

  • The SAGE score effectively identifies individuals at increased risk of arterial stiffness across different PWV thresholds.
  • The findings suggest the SAGE score's potential utility in non-hypertensive and pre-hypertensive individuals.
  • Development of a SAGE score specifically for normotensive and pre-hypertensive subjects is warranted.
Abstract

More Related Videos

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.1K
Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance14:09

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance

Published on: March 21, 2013

20.9K

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
36
Pre-Procedural Guidelines for Assessing Blood Pressure01:10

Pre-Procedural Guidelines for Assessing Blood Pressure

Accurate blood pressure assessment is crucial for diagnosing and managing various health conditions. To ensure the reliability of these measurements, healthcare professionals must adhere to standardized pre-procedural guidelines. These guidelines enhance patient safety and improve the overall quality of healthcare. The following steps are essential for obtaining accurate and consistent blood pressure readings, from using the appropriate tools to ensuring effective communication with the...
611
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
29
Assessment of blood pressure in brachial artery(two-step method)01:23

Assessment of blood pressure in brachial artery(two-step method)

Measuring blood pressure is a fundamental skill in healthcare that aids in diagnosing and monitoring hypertension and other cardiovascular conditions. An aneroid sphygmomanometer, commonly used in clinical settings, offers a manual and precise method for blood pressure measurement. The technique for using this instrument involves specific steps that must be carefully executed to ensure accuracy. The following detailed description outlines a two-step technique for assessing blood pressure using...
812
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
37
Assessment of blood pressure in brachial artery(one-step method)01:15

Assessment of blood pressure in brachial artery(one-step method)

This procedural guide systematically measures blood pressure using an oscillometric digital sphygmomanometer, emphasizing accuracy, patient safety, and comfort.
Prepare for the Procedure:
665