Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients

Nicholas C Allen1, Andrew J Martin1, Victoria A Snaidr1

  • 1From the Department of Dermatology, University of Sydney at Royal Prince Alfred Hospital (N.C.A., V.A.S., A.D.G., A.C.C., D.L.D.), the NHMRC (National Health and Medical Research Council) Clinical Trials Centre, University of Sydney (A.J.M., R.E.), and the Department of Renal Medicine (S.J.C.) and the A.W. Morrow Gastroenterology and Liver Centre (D.G.B.), Royal Prince Alfred Hospital, Camperdown, NSW, the Skin Health Institute, Carlton, VIC (A.H.C., K.J.A., R.B.D., B.P.M., T.K.), the Department of Dermatology, University of Sydney at Westmead Hospital, Westmead, NSW (P.F.-P.), the Department of Dermatology, the Alfred Hospital (D.G., A.D.G., J.N.), the Department of Anatomical Pathology, Alfred Health (C.M.), and the Department of Anatomical Pathology, Royal Melbourne Hospital (A. Landgren), Melbourne, VIC, the Department of Dermatology, Royal Adelaide Hospital (S.S., C.A., B.W., B.S.), and South Australia Pathology (J.I.), Adelaide, SA, the Department of Dermatology, University of New South Wales at St. Vincent's Hospital (V.L.P., N.D.R., T.S.), NSW Health Pathology (C.A.M., R.A.S.), the Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital (C.A.M., R.A.S.), Faculty of Medicine and Health (R.A.S., J.L.V., D.G.B.), Melanoma Institute Australia (R.A.S., D.L.D.), Charles Perkins Centre (R.A.S., S.J.C.), and the Centre for Medical Psychology and Evidence-Based Decision-Making (H.M.D., J.L.V.), University of Sydney, and the Liver Immunology Program, the Centenary Institute, University of Sydney and Royal Prince Alfred Hospital (D.G.B.), Sydney, the Departments of Dermatology (L.A.B., H.S., A.D., A.T., H.G., H.A.E.) and Pathology (A.D.), Sunshine Coast University Hospital, Griffith University Medical School (L.A.B.), and the School of Health and Behavioural Sciences, University of the Sunshine Coast (A.D.), Birtinya, QLD, the Department of Dermatology, University of Sydney at Royal North Shore Hospital, St. Leonards, NSW (A. Lim), the Department of Dermatology, Royal Melbourne Hospital, Parkville, VIC (E.U., B.J.D., Y.K., K.S., Z.M.L.), the Dermatology Research Centre, Diamantina Institute, the University of Queensland (H.S., H.A.E.), and the Department of Dermatology, Princess Alexandra Hospital (H.A.E.), Woolloongabba, QLD, Melbourne Pathology, Sonic Healthcare, Collingwood, VIC (S.P.), Southern.IML Pathology, Sonic Healthcare, Coniston, NSW (A. Lochhead), Wollongong Hospital, Wollongong, NSW (A. Lochhead), the School of Medicine, University of Queensland, Herston (A.T.), and the Department of Medicine, Concord Clinical School, University of Sydney, and Concord Cancer Centre, Concord Repatriation General Hospital, Concord, NSW (J.L.V.) - all in Australia.

Summary

Oral nicotinamide (vitamin B3) did not prevent new skin cancers in organ transplant recipients. This study found no significant difference in keratinocyte cancers or actinic keratoses between patients taking nicotinamide or a placebo.

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