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Related Experiment Video

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Ultra-High Resolution Optical Aberrometry in Patients with Keratoconus: A Cross-Sectional Study.

Gonzalo Velarde-Rodriguez1, Carolina Belda-Para2, Miriam Velasco-Ocaña2

  • 1Fundación Jiménez Díaz University Hospital, Avda. Reyes Católicos, 2, Madrid, Spain. gonzalo.velarde@quironsalud.es.

Ophthalmology and Therapy
|March 1, 2023
PubMed
Summary

A novel ultra-high-resolution aberrometer accurately measures ocular aberrations, revealing distinct wavefront patterns in keratoconus patients compared to healthy individuals. This technology shows promise for improved screening and follow-up of corneal diseases.

Keywords:
AberrometryCorneaKeratoconusOptical aberrationOptics

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Area of Science:

  • Ophthalmology
  • Optical Engineering
  • Medical Imaging

Background:

  • Accurate assessment of optical aberrations is crucial for understanding visual quality and diagnosing eye conditions.
  • Keratoconus is a progressive corneal disease characterized by irregular astigmatism and visual distortion.
  • High-order aberrations, beyond the 10th order of Zernike coefficients, play a significant role in visual perception.

Purpose of the Study:

  • To assess optical aberrations, particularly high-order wavefront aberrations, using a novel ultra-high-resolution aberrometer.
  • To compare ocular and corneal aberrations between patients with keratoconus and healthy individuals.
  • To investigate the utility of a high-resolution aberrometer for detecting subtle changes in wavefront phase.

Main Methods:

  • A cross-sectional study involving 43 eyes from 25 healthy patients and 43 eyes from 27 keratoconus patients.
  • Utilized a novel ultra-high-resolution aberrometer prototype (T-eyede) with an astrophysics-derived sensor.
  • Corneal aberrations were modeled using Zemax optical software, while ocular aberrations were measured by T-eyede; wavefront phase analysis included a high-pass filter map.

Main Results:

  • Ocular aberrations were significantly lower than corneal aberrations in both groups (p < 0.001).
  • The keratoconus group exhibited significantly higher wavefront aberration values compared to controls (p < 0.001).
  • A high-pass filter map revealed a smooth pattern in 95% of controls and a banding pattern in 77% of keratoconus patients (p < 0.001).

Conclusions:

  • The T-eyede device provides reliable and precise ocular aberration measurements that correlate with corneal aberrations.
  • Ultra-high-resolution measurements revealed unprecedented micro-changes in the wavefront phase of keratoconus patients, varying with disease stage.
  • These findings suggest potential for new screening and follow-up methods for keratoconus using advanced aberrometry.