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Hemoglobin Denver, a cause of desaturated pulse oximetry. A pediatric case report

Estefanía Rossetti1, Silvia Eandi Eberle2, Fernando Aguirre2

  • 1Department of Hematology and Oncology; Hospital de Pediatría S.A.M.I.C. Prof. Dr. Juan P. Garrahan, City of Buenos Aires, Argentina.

Archivos Argentinos De Pediatria
|March 1, 2023
PubMed

Hemoglobinopathies are genetic disorders that affect the hemoglobin (Hb) molecule. Mutations in the alpha or beta chains altering the Hb tetramer may modify the molecule's oxygen-binding capacity. Hemoglobinopathies with low oxygen affinity may occur with cyanosis and an altered pulse oximetry reading, leading to unnecessary and sometimes invasive tests to rule out cardiovascular and respiratory conditions. In the case report described here, we present an asymptomatic pediatric patient who consulted for desaturated pulse oximetry. Her initial laboratory tests showed normocytic, normochromic anemia. Venous blood gas samples showed an elevated p50. After using extensive diagnostic tools, a variant of Hb with low oxygen affinity was diagnosed: Hb Denver.

Keywords:
abnormal hemoglobinshemoglobin Denvertranscutaneous blood gas monitoring

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