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Antifungal Susceptibility Testing for Microsporum canis from Cats in Japan
Rui Kano1, Mai Watanabe2, Hitoshi Tsuchihashi2
1Teikyo University Institute of Medical Mycology (TIMM).
Abstract:
Control of infection caused by Microsporum canis in pet animals are important for prevention of zoonosis. Treatments for animal dermatophytosis have generally consisted of itraconazole (ITZ) and terbinafine (TRF); however, a TRF-resistant M. canis strain from a case of feline dermatophytosis has been reported. In the present study, we examined the in vitro susceptibility of clinical isolates of M. canis to new antifungal drugs, such as ravuconazole (RVZ) and luliconazole (LCZ). The results indicated that RVZ and LCZ are more effective than ITZ and TRF. Therefore, oral administration of RVZ or topical application of LCZ may serve as new treatment options.
Insights
New antifungal drugs, ravuconazole (RVZ) and luliconazole (LCZ), show greater effectiveness against Microsporum canis infections in pets compared to existing treatments. This offers promising new options for controlling zoonotic fungal diseases.
Area of Science:
- Veterinary Mycology
- Antimicrobial Resistance
- Zoonotic Disease Control
Background:
- * Controlling Microsporum canis infections in pets is crucial for preventing zoonotic transmission.
- * Established treatments like itraconazole (ITZ) and terbinafine (TRF) face challenges, including reported terbinafine resistance in M. canis strains.
Observation:
- * This study investigated the in vitro susceptibility of clinical M. canis isolates to novel antifungal agents.
- * Newer antifungals, ravuconazole (RVZ) and luliconazole (LCZ), were evaluated alongside itraconazole and terbinafine.
Findings:
- * Both ravuconazole (RVZ) and luliconazole (LCZ) demonstrated superior in vitro efficacy against M. canis compared to itraconazole (ITZ) and terbinafine (TRF).
- * The results highlight a significant difference in potency between the new and older antifungal drugs.
Implications:
- * Oral ravuconazole (RVZ) and topical luliconazole (LCZ) represent potential new therapeutic strategies for animal dermatophytosis.
- * These findings could lead to improved management of M. canis infections and reduced risk of zoonotic spread.
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