Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

64
Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
64
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

29
IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
29
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

20
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
20
Dysrhythmias III: Characteristics of Dysrhythmias01:29

Dysrhythmias III: Characteristics of Dysrhythmias

17
Dysrhythmias, also known as arrhythmias, are irregular heart rhythms that result from abnormal electrical activity in the heart, affecting its ability to circulate blood efficiently. Tachyarrhythmias, a subset of dysrhythmias, are characterized by abnormally fast heart rates exceeding 100 beats per minute. Here are some types of tachyarrhythmias with their distinct ECG features:Sinus Tachycardia:Sinus tachycardia presents a regular heart rhythm with an increased rate of 101-180 beats per...
17
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

27
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
27
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

25
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
25

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unlocking the Regulatory Genome: Interpreting the Clinical Impact of Noncoding Variants in Genetic Cardiomyopathies.

Circulation. Genomic and precision medicine·2026
Same author

Ringing the Alarm on Left-Ventricular and Biventricular Arrhythmogenic Cardiomyopathy.

JACC. Clinical electrophysiology·2026
Same author

Jailing of transvenous leads during transcutaneous tricuspid valve replacement: A perilous future?

HeartRhythm case reports·2026
Same author

Catheter ablation of epicardial premature ventricular complexes in patients with and without cardiac scar.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing·2026
Same author

Sex and Age Specific Genetic Risk Across the Dilated and Arrhythmogenic Cardiomyopathy Spectrum: Insights From the SHaRe Registry.

Journal of the American College of Cardiology·2026
Same author

Successful Bipolar Radiofrequency Ablation for Intramural Premature Ventricular Complexes Protected by Transcatheter Aortic Valve.

JACC. Clinical electrophysiology·2026
Same journal

Beyond the Earliest Signal: A Three-Dimensional Perspective on the Substrate and Strategy of Outflow Tract PVC Ablation.

JACC. Clinical electrophysiology·2026
Same journal

Catheter Ablation of ARVC Ventricular Tachycardia With a Reverse R-Wave Pattern Break in Lead V2.

JACC. Clinical electrophysiology·2026
Same journal

Beyond QRS Duration in Cardiac Resynchronization Therapy.

JACC. Clinical electrophysiology·2026
Same journal

The High Road Is Clear: Reassuring Evidence for Aortic Valve Safety During Aortic Cusp Ablation.

JACC. Clinical electrophysiology·2026
Same journal

Intracardiac Electrograms During Left Bundle Branch Area Pacing Implantation.

JACC. Clinical electrophysiology·2026
Same journal

Marshall Bundle-Mediated Re-Entry After Combined Endo- and Epicardial PFA at the Mitral Isthmus Successfully Treated With VOMEI.

JACC. Clinical electrophysiology·2026
See all related articles

Related Experiment Video

Updated: Aug 8, 2025

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
09:40

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice

Published on: May 13, 2019

10.6K

Left and Right PVC-Induced Ventricular Dysfunction.

Anurut Huntrakul1, Adam Helms2, Anil Attili3

  • 1Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA; Department of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

JACC. Clinical Electrophysiology
|March 1, 2023
PubMed
Summary
This summary is machine-generated.

Frequent premature ventricular complexes (PVCs) can lead to reversible right ventricular (RV) cardiomyopathy. Successful ablation of PVCs improves RV function, highlighting a new therapeutic target for RV dysfunction.

Keywords:
ablationcardiomyopathyfrequent premature ventricular complexesright ventricular function

More Related Videos

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

4.3K
Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding
10:39

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding

Published on: August 30, 2024

737

Related Experiment Videos

Last Updated: Aug 8, 2025

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
09:40

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice

Published on: May 13, 2019

10.6K
Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

4.3K
Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding
10:39

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding

Published on: August 30, 2024

737

Area of Science:

  • Cardiology
  • Electrophysiology
  • Cardiomyopathy Research

Background:

  • Frequent premature ventricular complexes (PVCs) are known to cause left ventricular (LV) dysfunction.
  • The impact of PVCs on right ventricular (RV) function has been less understood.

Purpose of the Study:

  • To investigate the effect of frequent PVCs on RV function.
  • To determine if RV dysfunction caused by PVCs is reversible.

Main Methods:

  • Serial cardiac magnetic resonance (CMR) imaging was used in 47 patients.
  • Patients underwent CMR before and after ablation of frequent PVCs.

Main Results:

  • Patients with RV or LV cardiomyopathy had significantly more frequent PVCs.
  • RV dysfunction was present in 40% of patients, with 9% having isolated RV dysfunction.
  • Successful PVC ablation led to significant improvement in RV function.

Conclusions:

  • Frequent PVCs can cause a reversible form of RV cardiomyopathy.
  • Ablation of frequent PVCs can restore normal RV function, similar to its effect on the LV.