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A cell-cycle constraint on the regulation of gene expression by platelet-derived growth factor
B J Rollins1, E D Morrison, C D Stiles
1Division of Medicine, Dana-Farber Cancer Institute, Boston, MA 02115.
Science (New York, N.Y.)
|November 27, 1987
Abstract:
In density-arrested monolayer cultures of Balb/c 3T3 cells, platelet-derived growth factor (PDGF) stimulates expression of the c-myc and c-fos proto-oncogenes, as well as the functionally uncharacterized genes, JE, KC, and JB. These genes are not coordinately regulated. Under ordinary conditions, c-fos, JE, KC, and JB respond to PDGF only when the cells are in a state of G0 growth arrest at the time of PDGF addition. The c-myc gene is regulated in opposition to the other genes, responding best to PDGF in cycling cultures.