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Flow Cytometry-based Assay for the Monitoring of NK Cell Functions
Published on: October 30, 2016
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Effects of epigenetic therapy on natural killer cell function and development in hematologic malignancy
Matthew R Lordo1,2, Andrew R Stiff1,3,4, Christopher C Oakes1,4
1Comprehensive Cancer Center, The Ohio State University, 460 W. 10th Avenue, Columbus, OH 43210, USA.
Journal of Leukocyte Biology
|March 2, 2023
Summary
Epigenetic therapies, including approved cancer drugs, impact natural killer (NK) cells. This review explores how these therapies affect NK cell development and function in cancer treatment.
Area of Science:
- Oncology
- Immunology
- Epigenetics
Background:
- Epigenetic therapy is a promising cancer treatment, particularly for hematologic malignancies.
- Approved agents include DNA hypomethylating agents, histone deacetylase inhibitors, IDH1/2 inhibitors, and EZH2 inhibitors.
- Current research often focuses on direct cancer cell effects, not immune system modulation.
Approach:
- This review synthesizes existing literature on epigenetic therapy's impact on natural killer (NK) cells.
- It examines various classes of epigenetic agents and their effects on NK cell development and function.
- The focus is on how these therapies influence the immune system's response to cancer.
Key Points:
- Epigenetic therapies can influence the development and function of natural killer (NK) cells.
- NK cells play a crucial role in immune surveillance against cancer.
- Understanding these interactions may reveal new therapeutic strategies.
Conclusions:
- Epigenetic therapy affects not only cancer cells but also the immune system, specifically NK cells.
- This immunomodulatory effect has significant implications for cancer treatment efficacy.
- Further research into epigenetic therapy's impact on NK cells is warranted.
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