Research Progress on N⁶-adenosylate Methylation RNA Modification in Heart Failure Remodeling

Cardiovascular disease (CVD) is the major cause of disability-adjusted life years (DALY) and death globally. The most common internal modification of mRNA is N⁶-adenosylate methylation (m⁶A). Recently, a growing number of studies have been devoted to researching cardiac remodeling mechanisms, especially m⁶A RNA methylation, revealing a connection between m⁶A and cardiovascular diseases. This review summarized the current understanding regarding m⁶A and elucidated the dynamic modifications of writers, erasers, and readers. Furthermore, we highlighted m⁶A RNA methylation related to cardiac remodeling and summarized its potential mechanisms. Finally, we discussed the potential of m⁶A RNA methylation in the treatment of cardiac remodeling.