Related Experiment Video
Updated: Aug 8, 2025
03:55
Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
578
[Synchronous Multiple Thymoma Suggested to be Multi-centric Origin:Report of a Case].
Mao Sato1, Seijiro Sato, Hirohiko Shinohara
1Division of General Thoracic Surgery, Nagaoka Red Cross Hospital, Nagaoka, Japan.
Kyobu Geka. the Japanese Journal of Thoracic Surgery
|March 2, 2023
Summary
A 57-year-old man presented with two anterior mediastinal nodules. Surgical removal and histopathology confirmed both as type B1 thymomas, suggesting a rare multi-centric origin.
Area of Science:
- Thoracic surgery
- Oncology
- Pathology
Background:
- A 57-year-old male presented with an incidental finding of an abnormal shadow on chest X-ray.
- Initial investigations included computed tomography (CT) and positron emission tomography (PET) revealing two anterior mediastinal nodules.
Observation:
- The nodules, one cystic, showed mild fluorodeoxyglucose uptake on PET.
- Surgical exploration via thoracoscopic thymo-thymectomy identified two distinct tumors within the thymus.
Findings:
- Histopathological examination confirmed both nodules as encapsulated type B1 thymomas.
- Tumor sizes were 35 mm and 40 mm.
- The lack of continuity between tumors suggested a multi-centric origin.
Implications:
- This case highlights the possibility of multi-centric origin for thymomas.
- Accurate diagnosis and surgical management are crucial for thymic tumors.
Related Concept Videos
02:21Cancers Originate from Somatic Mutations in a Single Cell
12.4K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
12.4K
01:15Secondary Lymphoid Organs
1.8K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
1.8K
01:23The Thyroid Gland
4.1K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.1K
01:16Primary Lymphoid Organs
2.7K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
2.7K
02:07Tumor Progression
6.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.4K
01:27Tumor Immunotherapy
611
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
611