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An overview on liquisolid technique: its development and applications
Amira Rashad1, Dina Louis1,2
1Department of Pharmaceutics & Pharmaceutical Technology, Faculty of Pharmacy, Heliopolis University, Egypt.
Therapeutic Delivery
|March 2, 2023
Summary
The liquisolid technique enhances drug dissolution and controls release using modified carriers and novel methods like liquipellets and liquiground. This review details recent advancements in this cost-effective formulation approach.
Area of Science:
- Pharmaceutical Sciences
- Formulation Development
- Drug Delivery Systems
Background:
- The liquisolid technique is a simple, cost-effective method for addressing formulation challenges.
- It has been successfully applied to enhance drug dissolution and achieve sustained drug release.
Purpose of the Study:
- To review the latest advancements in the liquisolid technique.
- To highlight novel modifications and applications of this formulation strategy.
Main Methods:
- Discussion of modified additives as carrier materials for increased surface area.
- Introduction of the liquipellet technique, derived from extrusion/palletization.
- Explanation of the liquiground concept, merging co-grinding with liquisolid principles.
- Mention of Eudragits and hydrophilic polymers for sustained release mechanisms.
Main Results:
- Modified additives provide necessary surface area for liquid encapsulation.
- Liquipellet and liquiground techniques offer new avenues for liquisolid formulations.
- Specific polymers enable effective control over drug release rates.
Conclusions:
- The liquisolid technique continues to evolve with innovative approaches.
- Recent developments expand its utility in drug formulation and delivery.
- This technique remains a valuable tool for dissolution enhancement and controlled release.
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