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Updated: Aug 8, 2025

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Facilitating [2+2] Photocycloadditions by Promoting Oxygen Tolerance and Substrate Activation in Water
Julian C G Kürschner1, Linda Brüss1, Line Naesborg1
1Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstraße 36, 48149, Münster, Germany.
Abstract:
Micellar photocatalysis has been used to overcome oxygen quenching and enable a [2+2] photocycloaddition through triplet-energy transfer in water under aerobic conditions. The cheap and commercially available self-assembling sodium dodecyl sulfate (SDS) micelles were found to increase the oxygen tolerance of a typically oxygen-sensitive reaction. Furthermore, the use of the micellar solution was found to activate α,β-unsaturated carbonyl compounds to energy transfer and allow [2+2] photocycloadditions to take place. Our preliminary studies of micellar effects on energy-transfer-based reactions demonstrate the reaction between α,β-unsaturated carbonyl compounds and activated alkenes in a mixture of SDS, water and [Ru(bpy)3 ](PF6 )2 .
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