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Phage Display Screening as a Rational Approach to Design Additives for Selective Crystallization Control in

Benjamin Madeja1, Patrick Wilke2, Eduard Schreiner3

  • 1Physical Chemistry, University of Konstanz, Universitätsstr. 10, D-78464, Konstanz, Germany.

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|March 2, 2023
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Summary
This summary is machine-generated.

Bioinspired phage display identified a DYH amino acid motif that selectively controls gypsum crystallization. This discovery enables the development of advanced cement additives for improved construction materials.

Keywords:
cementitious materialsconstructioncrystallizationgypsumnext-generation sequencingphage displayselective hydration control

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Area of Science:

  • Materials Science
  • Biotechnology
  • Mineralogy

Background:

  • Controlling crystallization in reactive systems is crucial for materials development.
  • Traditional methods for finding additives are often inefficient and limited in scope.
  • Bioinspired approaches offer a rational strategy for discovering novel functional molecules.

Purpose of the Study:

  • To identify specific molecular motifs that interact with crystalline gypsum surfaces.
  • To develop selective crystallization additives for cement hydration processes.
  • To translate peptide-based discoveries into scalable synthetic copolymers.

Main Methods:

  • Phage display screening to identify surface-binding peptides.
  • Next-generation sequencing for analyzing enriched phage populations.
  • Testing peptide and copolymer performance in cement hydration.

Main Results:

  • A DYH amino acid triplet was identified as a key motif for gypsum adsorption.
  • Oligopeptides containing DYH selectively retarded cement sulfate reactions (initial setting) without affecting silicate reactions (hardening).
  • The additive properties were successfully transferred from peptides to synthetic copolymers.

Conclusions:

  • Phage display is an effective tool for discovering functional crystallization additives.
  • The DYH motif offers a pathway for developing advanced cement additives.
  • Biotechnological methods can accelerate materials science innovation.