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Protocol to assemble metal-phenolic framework nanoparticles based on polyphenol-mediated biomimetic mineralization
Xiaolong Zhan1, Zhengbo Wen2, Yuxin Chen2
1MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong 510006, China.
Abstract:
Here, we present a protocol for controllable biomimetic mineralization at the nano-scale, simulating natural ion-enriched sedimentary mineralization. We describe steps for treatment of metal-organic frameworks with polyphenol-mediated stabilized mineralized precursor solution. We then detail their use as templates to assemble metal-phenolic frameworks (MPFs) with mineralized layers. Furthermore, we demonstrate the therapeutic benefits of MPF delivery by hydrogel to the full-thickness skin defect model in rats. For complete details on the use and execution of this protocol, please refer to Zhan et al. (2022).1.
