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Repeat chymopapain injections. Results and complications.
1Department of Orthopaedic Surgery, Shaughnessy Hospital/University of British Columbia, Vancouver.
Spine
|October 1, 1987
Summary
Repeat chymopapain injections offer potential benefits for patients with protruded discs, with over 70% experiencing some improvement. However, significant risks of anaphylactic reactions necessitate further safety research before widespread use.
Area of Science:
- * Minimally Invasive Spine Procedures
- * Interventional Pain Management
Background:
- * Chymopapain injections have been used to treat protruded intervertebral discs.
- * The efficacy and safety of repeat injections require further investigation.
Purpose of the Study:
- * To evaluate the outcomes of repeat chymopapain injections in patients with protruded discs.
- * To assess the safety profile, including adverse reactions, of repeat chymopapain administration.
Main Methods:
- * Retrospective review of 35 patients who underwent repeat chymopapain injections.
- * Analysis of treatment outcomes (excellent, some improvement, no improvement) and adverse events.
Main Results:
- * Overall, 41% of patients had excellent results, and 37% had some improvement after repeat injections.
- * 17% of patients experienced anaphylactic reactions, with 5 major reactions reported.
- * No significant difference in outcomes was observed between patients receiving repeat injections in the same or different discs.
Conclusions:
- * Repeat chymopapain injection may be a viable treatment option for protruded discs.
- * Development of a definitive sensitivity test is crucial to mitigate anaphylactic risks before repeat administration.