Related Experiment Video

Updated: Aug 8, 2025

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury
07:58

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Published on: July 17, 2016

8.9K

Acute Kidney Injury Among Children Likely Associated with Diethylene Glycol-Contaminated Medications - The Gambia,

Parsa Bastani, Anna Jammeh, Frederica Lamar

    MMWR. Morbidity and Mortality Weekly Report
    |March 2, 2023
    PubMed

    Insights

    Contaminated syrup-based medications caused a severe acute kidney injury (AKI) outbreak in Gambian children. Health officials recalled the drugs and recommend enhanced surveillance to prevent future medication-related public health emergencies.

    Area of Science:

    • Public Health
    • Epidemiology
    • Pediatric Nephrology

    Background:

    • A cluster of acute kidney injury (AKI) cases in children was reported in The Gambia in July 2022.
    • The Ministry of Health (MoH) requested assistance from the Centers for Disease Control and Prevention (CDC) to investigate the outbreak.

    Purpose of the Study:

    • To characterize the illness and epidemiology of the AKI outbreak.
    • To identify potential causal factors and sources of the outbreak.
    • To inform public health interventions and prevent future occurrences.

    Main Methods:

    • Review of medical records of affected children.
    • Interviews with caregivers to identify exposures.
    • Collaboration between The Gambia's MoH and CDC.

    Main Results:

    • Preliminary investigation implicated contaminated syrup-based children's medications as the likely cause of the AKI outbreak.
    • The MoH recalled medications from a single international manufacturer.
    • The outbreak highlighted vulnerabilities in pharmaceutical quality control and surveillance.

    Conclusions:

    • Strengthening pharmaceutical quality control is crucial.
    • Enhancing event-based public health surveillance is necessary.
    • Preventing future medication-related outbreaks requires a multi-faceted approach.

    More Related Videos

    Intravenous Microinjections of Zebrafish Larvae to Study Acute Kidney Injury15:55

    Intravenous Microinjections of Zebrafish Larvae to Study Acute Kidney Injury

    Published on: August 4, 2010

    22.7K
    A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion09:02

    A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

    Published on: February 2, 2021

    4.5K

    Related Concept Videos

    Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

    Acute Kidney Injury IV: Diagnostic Studies and Prevention

    Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
    49
    Acute Kidney Injury III: Clinical Manifestations01:29

    Acute Kidney Injury III: Clinical Manifestations

    Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
    54
    Acute Kidney Injury V: Interprofessional Care01:20

    Acute Kidney Injury V: Interprofessional Care

    Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
    38
    Acute Kidney Injury I: Introduction01:22

    Acute Kidney Injury I: Introduction

    Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
    49
    Acute Kidney Injury II: Pathophysiology01:29

    Acute Kidney Injury II: Pathophysiology

    Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
    41
    Acute Kidney Injury VI: Nursing Management01:22

    Acute Kidney Injury VI: Nursing Management

    Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
    43