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Healthy Vaccinee Bias and MenB-FHbp Vaccine Effectiveness Against Gonorrhea
Winston E Abara1, Kyle T Bernstein1, Felicia M T Lewis
1From the Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
Abstract:
Observational studies demonstrated 30% to 40% effectiveness of outer-membrane vesicle (OMV) meningococcal serogroup B vaccines against gonorrhea. To explore whether healthy vaccinee bias influenced such findings, we examined the effectiveness of MenB-FHbp, a non-OMV vaccine that is not protective against gonorrhea. MenB-FHbp was ineffective against gonorrhea. Healthy vaccinee bias likely did not confound earlier studies of OMV vaccines.
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