Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Experimental RNAi

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Immunonutrition supplementation for resectable gastric cancer during standard neoadjuvant chemotherapy of FLOT. A proof-of-concept protocol: I-SUPPLY.

ESMO gastrointestinal oncology·2026

Same author

Leptin as a surrogate immune-metabolic marker to predict impact of anti-cachectic therapy: results of a prospective randomized trial in multiple solid tumors.

ESMO open·2024

Same author

Fibronectin type III domain-containing protein 5 (FNDC5)-like immunoreactivity and mRNA abundance in domestic animal tissues.

Veterinary journal (London, England : 1997)·2024

Same author

Multidisciplinary clinical guidelines in proactive monitoring, early diagnosis, and effective management of trastuzumab deruxtecan (T-DXd)-induced interstitial lung disease (ILD) in breast cancer patients.

ESMO open·2023

Same author

Serum calcium levels are associated with cognitive function in hypoparathyroidism: a neuropsychological and biochemical study in an Italian cohort of patients with chronic post-surgical hypoparathyroidism.

Journal of endocrinological investigation·2022

Same author

The role of fetal programming in human carcinogenesis - May the Barker hypothesis explain interindividual variability in susceptibility to cancer insurgence and progression?

European review for medical and pharmacological sciences·2022

Search research articles

Related Experiment Video

Updated: Aug 8, 2025

Intravitreal Injections in the Ovine Eye

Intravitreal Injections in the Ovine Eye

Published on: July 5, 2022

Irisin in domestic animals.

E Lai¹, S Unniappan¹

¹Department of Veterinary Biomedical Sciences, Laboratory of Integrative Neuroendocrinology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4, Canada.

Domestic Animal Endocrinology

|March 2, 2023

Summary

This summary is machine-generated.

Irisin, a hormone from fibronectin type III domain-containing protein, aids energy expenditure and fat browning in vertebrates. Further research into irisin in domestic animals may yield new therapeutic agents and biomarkers.

Keywords:

Domestic animals Irisin Mammals Metabolism Vertebrates Veterinary Medicine

More Related Videos

Isolation, Culture, and Genetic Engineering of Mammalian Primary Pigment Epithelial Cells for Non-Viral Gene Therapy

Isolation, Culture, and Genetic Engineering of Mammalian Primary Pigment Epithelial Cells for Non-Viral Gene Therapy

Published on: February 26, 2021

Biomolecular Detection employing the Interferometric Reflectance Imaging Sensor IRIS

Biomolecular Detection employing the Interferometric Reflectance Imaging Sensor IRIS

Published on: May 3, 2011

Related Experiment Videos

Last Updated: Aug 8, 2025

Intravitreal Injections in the Ovine Eye

Intravitreal Injections in the Ovine Eye

Published on: July 5, 2022

Isolation, Culture, and Genetic Engineering of Mammalian Primary Pigment Epithelial Cells for Non-Viral Gene Therapy

Isolation, Culture, and Genetic Engineering of Mammalian Primary Pigment Epithelial Cells for Non-Viral Gene Therapy

Published on: February 26, 2021

Biomolecular Detection employing the Interferometric Reflectance Imaging Sensor IRIS

Biomolecular Detection employing the Interferometric Reflectance Imaging Sensor IRIS

Published on: May 3, 2011

Area of Science:

Endocrinology
Veterinary Medicine
Molecular Biology

Background:

Irisin is a peptide hormone derived from the fibronectin type III domain-containing protein.
It plays a role in browning white adipose tissue and increasing energy expenditure.
Irisin is conserved across vertebrates, indicating shared functions in domestic animals.

Purpose of the Study:

To review the current understanding of irisin structure, tissue distribution, and functions in vertebrates.
To focus on the relevance of irisin in mammals significant to veterinary medicine.
To explore irisin's potential as a therapeutic agent and biomarker in domestic animal endocrinology.

Main Methods:

Literature review of existing studies on irisin.
Analysis of irisin's presence and function across different vertebrate species.
Synthesis of information regarding irisin's role in domestic animal physiology.

Main Results:

Irisin is found in various tissues beyond plasma and muscle, including adipose tissue, liver, kidney, and more.
Its presence suggests functions beyond energy expenditure regulation.
The review consolidates current knowledge on irisin in vertebrates, with an emphasis on domestic animals.

Conclusions:

Irisin's widespread tissue distribution indicates diverse physiological roles.
Understanding irisin in domestic animals is advancing.
Irisin holds promise for developing novel therapeutic strategies and diagnostic biomarkers in veterinary endocrinology.