First live birth after uterine transposition

Area of Science:

• Reproductive medicine
• Gynecologic oncology
• Surgical innovation

Background:

• Pelvic radiotherapy poses a risk of infertility due to its impact on the uterus.
• Uterine transposition (UT) is a surgical technique to move the uterus out of the radiation field.
• Preserving fertility in young cancer patients is a critical aspect of survivorship care.

Observation:

• A 28-year-old woman with synchronous liposarcoma underwent UT before pelvic and thoracic radiotherapy.
• Following radiotherapy, the uterus was surgically reimplanted into the pelvis.
• The patient conceived spontaneously 2 years after treatment.

Findings:

• Successful live birth of a healthy male infant at 36 weeks gestation via cesarean section.
• Both mother and child experienced an uneventful recovery and discharge.
• One-year follow-up confirmed normal infant development and no signs of cancer recurrence in the patient.

Implications:

• Uterine transposition is a viable strategy to preserve fertility in women undergoing pelvic radiotherapy.
• This case establishes a proof-of-concept for live birth after UT, radiotherapy, and uterine reimplantation.
• Offers hope for future fertility in young cancer survivors treated with pelvic radiation.