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Mitochondria

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...

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Related Experiment Video

Updated: Aug 8, 2025

Imaging and Quantifying Mitochondrial Morphology in C. elegans During Aging

Imaging and Quantifying Mitochondrial Morphology in C. elegans During Aging

Published on: January 17, 2025

Mitochondrial stress and aging: Lessons from C. elegans.

Peng X Chen¹, Leyuan Zhang¹, Di Chen²

¹State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100093, China.

Seminars in Cell & Developmental Biology

|March 2, 2023

Summary

Mitochondrial dysfunction accelerates aging but can paradoxically extend lifespan. Research in Caenorhabditis elegans reveals mitochondria

Keywords:

Aging C. elegans Longevity Mitochondrial stress Mitokine

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Last Updated: Aug 8, 2025

Imaging and Quantifying Mitochondrial Morphology in C. elegans During Aging

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Published on: January 17, 2025

Measurements of Physiological Stress Responses in C. Elegans

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Published on: May 21, 2020

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

Area of Science:

Gerontology
Mitochondrial Biology
Molecular Biology

Background:

Aging is linked to declining mitochondrial function, contributing to age-related diseases.
Paradoxically, impaired mitochondrial function is associated with increased lifespan in some studies.
Mitochondria play complex roles beyond energy production, acting as signaling platforms.

Purpose of the Study:

To review the role of Caenorhabditis elegans in understanding mitochondrial function in aging.
To explore how C. elegans research informs mitochondrial-targeted strategies for aging in higher organisms.

Main Methods:

Literature review of studies on aging and mitochondrial function in C. elegans.
Analysis of genetic pathways influencing mitochondrial roles in aging.
Synthesis of findings to project future research directions.

Main Results:

C. elegans has been crucial in dissecting the genetic basis of mitochondrial roles in aging.
Disruption of mitochondrial function in C. elegans can lead to extended lifespan.
Mitochondria are recognized as key regulators of cellular homeostasis and organismal health.

Conclusions:

Insights from C. elegans research have reshaped our understanding of mitochondria in aging.
Targeting mitochondrial pathways may offer strategies to slow aging and prevent age-related diseases in humans.
Further research in higher organisms is warranted to translate C. elegans findings.