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Tony Durand1, Perrine Paul-Gilloteaux2,3, Michalina Gora4,5

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Summary
This summary is machine-generated.

Full-field optical coherence tomography (FFOCT) visualizes enteric nervous system cells without dyes. Dynamic FFOCT detects functional changes in neurons and glia, offering a novel research tool.

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Area of Science:

  • Neuroscience
  • Biomedical Imaging
  • Gastroenterology

Background:

  • Current methods for studying enteric nervous system (ENS) function often use contrast dyes.
  • Exogenous dyes can interfere with cellular functions and survival, limiting research accuracy.
  • There is a need for non-invasive imaging techniques for ENS research.

Purpose of the Study:

  • To investigate the utility of full-field optical coherence tomography (FFOCT) for visualizing and analyzing ENS cells.
  • To assess FFOCT's capability in detecting functional changes in enteric neurons and glia.

Main Methods:

  • Whole-mount preparations of unfixed mouse colons were used.
  • Full-field optical coherence tomography (FFOCT) was employed for imaging.
  • Dynamic FFOCT was utilized to observe cellular activity and responses to stimuli.

Main Results:

  • FFOCT successfully visualized the myenteric plexus network in mouse colons.
  • Dynamic FFOCT enabled in situ visualization and identification of individual cells within myenteric ganglia.
  • The dynamic FFOCT signal responded to external stimuli like veratridine and osmolarity changes.

Conclusions:

  • Dynamic FFOCT is a promising non-invasive technique for studying ENS cell function.
  • This method can detect functional alterations in enteric neurons and glia under various conditions.
  • FFOCT offers a valuable tool for research in normal and disease states of the enteric nervous system.