[Clinico-morphological features and the course of glomerulonephritis in hemorrhagic vasculitis]

Peculiarities of a clinical course and prognosis of glomerulonephritis in Schönlein-Henoch disease (SH-nephritis) were studied in 42 adult patients. The 5- and 10-year survival rates were 87% and 72%, respectively. Of unfavorable prognostic value were proteinuria over 1 g/l, nephrotic syndrome, particularly combined with hypertension, marked stable microhematuria, and the detection of diffuse fibroplastic, extracapillary, and mesangiocapillary nephritis on biopsy. SH-nephritis was characterized by a more severe course in male patients, in persons aged over 30, and in the involvement of the kidneys one year and more after the appearance of the first clinical signs of skin vasculitis. The level of blood serum IgA and the gravity of skin vasculitis had no prognostic importance.