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[Chronic active hepatitis and pregnancy].

Z G Aprosina, T M Ignatova, M M Shekhtman

    Terapevticheskii Arkhiv
    |January 1, 1987
    PubMed
    Summary
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    Pregnancies in women with chronic active hepatitis (CAH) can be successfully managed, though risks like exacerbations and adverse fetal outcomes exist, especially with undiagnosed liver cirrhosis.

    Area of Science:

    • Hepatology
    • Obstetrics
    • Immunology

    Background:

    • Chronic active hepatitis (CAH) presents unique challenges during pregnancy.
    • Understanding the impact of CAH on pregnancy outcomes is crucial for patient management.

    Purpose of the Study:

    • To evaluate the course and outcomes of pregnancies in patients with chronic active hepatitis.
    • To identify risk factors for adverse pregnancy events in CAH patients.

    Main Methods:

    • Retrospective analysis of 211 pregnancies in 61 patients with CAH.
    • Assessment of pregnancy termination types, maternal health, and infant outcomes.
    • Comparison of outcomes based on underlying CAH etiology and presence of liver cirrhosis.

    Main Results:

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    • Successful pregnancy termination occurred in 38% of cases; 56% were medical abortions.
    • CAH exacerbations occurred in 38% of pregnancies, more severe in undiagnosed liver cirrhosis.
    • Maternal mortality was zero; however, pregnancy negatively impacted outcomes with 9% premature delivery and 75% perinatal mortality.

    Conclusions:

    • Pregnancy management in CAH patients can be successful with appropriate care, even with immunosuppressive therapy.
    • Undiagnosed liver cirrhosis significantly increases risks during pregnancy.
    • While mothers' survival is high, adverse fetal outcomes like prematurity and perinatal mortality require careful monitoring and intervention.