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An oncospace for human cancers.

Guim Aguadé-Gorgorió1,2,3, José Costa4, Ricard Solé2,3,5

  • 1ISEM, CNRS, IRD, EPHE, University of Montpellier, Montpellier, France.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|March 2, 2023
PubMed
Summary
This summary is machine-generated.

Researchers defined the oncospace, a novel framework integrating ecological, evolutionary, and developmental factors to understand cancer complexity. This approach maps tumor progression and may reveal new therapeutic strategies by targeting evolutionary dead ends.

Keywords:
cancer morphospacedevelopmental abnormalitiesgenome instabilitymicroenvironmental complexity

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Area of Science:

  • Oncology
  • Evolutionary Biology
  • Systems Biology

Background:

  • Human cancers are diverse diseases influenced by host-tumor interactions.
  • Understanding the underlying order in cancer progression is crucial for developing effective therapies.
  • Existing frameworks struggle to capture the full complexity of cancer heterogeneity.

Purpose of the Study:

  • To define a comprehensive framework, the oncospace, for understanding cancer complexity.
  • To integrate ecological, evolutionary, and developmental dimensions of tumor progression.
  • To explore the potential of oncospace topology for predicting prognosis and guiding treatment.

Main Methods:

  • Development of the oncospace as a coordinate system.
  • Analysis of tumor progression trajectories along ecological, evolutionary, and developmental axes.
  • Postulation of oncospace topology's role in tumorigenesis and therapeutic targeting.

Main Results:

  • The oncospace integrates key components of cancer complexity.
  • Tumor position in oncospace reflects departure from healthy tissue.
  • Progression trajectories reveal drivers of malignancy across subtypes.

Conclusions:

  • The oncospace framework offers a new perspective on cancer heterogeneity.
  • Oncospace topology may encode prognostic and therapeutic information.
  • Targeting evolutionary dead ends within the oncospace presents a novel therapeutic strategy.