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Updated: Aug 8, 2025

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy

Published on: September 29, 2016

DNA-based customized functional modules for signal transformation.

Mingzhi Zhang¹, Yang Sun¹

¹Institute of Molecular Medicine (IMM), Renji Hospital, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Frontiers in Chemistry

|March 3, 2023

Summary

This summary is machine-generated.

DNA functional modules offer a novel way to simultaneously track intracellular and extracellular biomolecules. These DNA-based systems transform biological signals into genetic information for enhanced disease monitoring.

Keywords:

DNA computing DNA functional modules DNA network molecular sensing signal transformation

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Last Updated: Aug 8, 2025

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy

Published on: September 29, 2016

Identification of Functional Protein Regions Through Chimeric Protein Construction

Identification of Functional Protein Regions Through Chimeric Protein Construction

Published on: January 8, 2019

Rapid Development of Cell State Identification Circuits with Poly-Transfection

Rapid Development of Cell State Identification Circuits with Poly-Transfection

Published on: February 24, 2023

Area of Science:

Biotechnology
Molecular Biology
Systems Biology

Background:

Understanding cellular molecule dynamics is key to disease progression insights.
Simultaneous intracellular and extracellular sensing is challenging due to accessibility and throughput limitations.

Purpose of the Study:

To summarize DNA-based functional modules for biomolecular signal sensing and transformation.
To review designs, applications, challenges, and future prospects of these DNA modules.

Main Methods:

Utilizing DNA as a material for in vivo and in vitro functional modules.
Designing DNA networks to transform bio-information into ATCG sequence information.
Employing principles of kinetics or thermodynamics for molecular information gathering.

Main Results:

DNA functional modules can monitor molecular identity, concentration, order, duration, location, and interactions.
These modules enable simultaneous acquisition of intracellular and extracellular data.
Advances in customized strategies have led to diverse DNA network designs.

Conclusions:

DNA-based functional modules present a powerful platform for comprehensive biomolecular monitoring.
They offer a promising avenue for improved understanding of biological processes and diseases.
Further development is needed to address current challenges and unlock full potential.