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Sedatives and Hypnotics: Overview01:23

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Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
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The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
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Method for Simultaneous fMRI/EEG Data Collection during a Focused Attention Suggestion for Differential Thermal Sensation
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Physicians' attitudes toward hypnotics for insomnia: A questionnaire-based study.

Masahiro Takeshima1, Yumi Aoki2,3, Kenya Ie4

  • 1Department of Neuropsychiatry, Akita University Graduate School of Medicine, Akita, Japan.

Frontiers in Psychiatry
|March 3, 2023
PubMed
Summary
This summary is machine-generated.

Physicians favor novel hypnotics like orexin receptor antagonists (ORA) for efficacy and safety. However, they often prioritize efficacy over safety when prescribing older drugs such as benzodiazepines.

Keywords:
benzodiazepinemelatonin receptor agonistnon-benzodiazepineorexin receptor antagonistquestionnaire survey

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Area of Science:

  • Pharmacology
  • Medical Practice
  • Sleep Medicine

Background:

  • Benzodiazepines and non-benzodiazepines remain widely prescribed hypnotics.
  • Novel hypnotics, including orexin receptor antagonists (ORA) and melatonin receptor agonists (MRA), are available but their prescription patterns may be influenced by physician attitudes.

Purpose of the Study:

  • To investigate physicians' attitudes toward different classes of hypnotics.
  • To understand the reasons behind the selection of frequently prescribed hypnotics.

Main Methods:

  • A questionnaire survey was conducted among 962 physicians.
  • Data were collected between October 2021 and February 2022.
  • Logistic regression analysis was used to compare frequent and non-frequent prescribers.

Main Results:

  • Orexin receptor antagonists (ORA) were the most frequently prescribed hypnotic (84.3%).
  • Frequent prescribers of ORA, MRA, and non-benzodiazepines showed higher concern for efficacy and/or safety.
  • Frequent benzodiazepine prescribers prioritized efficacy over safety.

Conclusions:

  • Physicians perceive ORA as an effective and safe hypnotic option.
  • The study suggests a tendency to prioritize efficacy over safety when prescribing benzodiazepines and non-benzodiazepines.