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Exploring the association and causal effect between white blood cells and psoriasis using large-scale population data
Guowei Zhou1,2,3, Xiangmei Ren1,2,3, Zhenwei Tang1,2,3
1Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Frontiers in Immunology
|March 3, 2023
Summary
High levels of monocytes, neutrophils, and eosinophils are associated with increased psoriasis risk. Eosinophils show a causal link, and ratios like NLR and PLR are risk factors, offering insights for psoriasis treatment.
Area of Science:
- Immunology
- Dermatology
- Genetics
Background:
- Psoriasis is a chronic inflammatory skin disease.
- It is considered immune-mediated, involving various immune cells.
- The specific role of circulating immune cells in psoriasis is not fully understood.
Purpose of the Study:
- To investigate the association between circulating white blood cells and psoriasis.
- To evaluate the potential causal relationship between leukocytes and psoriasis using genetic data.
Main Methods:
- Observational study involving 361,322 individuals from the UK Biobank and 3,971 Chinese psoriasis patients.
- Genome-wide association studies (GWAS) were performed.
- Mendelian randomization (MR) analysis was utilized to assess causality.
Main Results:
- Increased psoriasis risk correlated with higher monocyte, neutrophil, and eosinophil levels.
- Eosinophils demonstrated a causal relationship with psoriasis and correlated with disease severity (PASI score).
- Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) were identified as risk factors, while lymphocyte-monocyte ratio (LMR) was protective; these ratios also correlated with PASI scores.
Conclusions:
- Circulating leukocytes, particularly eosinophils, monocytes, and neutrophils, are significantly associated with psoriasis.
- Immune cell profiles and ratios provide valuable insights for clinical management and treatment strategies in psoriasis.
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