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Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Comprehensive genomic profiling: Does timing matter?

Bicky Thapa¹, Gulrayz Ahmed¹, Aniko Szabo²

¹Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, United States.

Frontiers in Oncology

|March 3, 2023

Summary

This summary is machine-generated.

Comprehensive Genomic Profiling (CGP) utilization in metastatic solid tumors (MST) varied by cancer type but was equitable across demographics. Early CGP after diagnosis may improve outcomes for certain cancers with actionable targets.

Keywords:

best practice comprehensive genomic profiling disparities metastatic solid tumors precision oncology

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Area of Science:

Oncology
Genomics
Cancer Research

Background:

Variability exists in the utilization of Comprehensive Genomic Profiling (CGP) for metastatic solid tumors (MST).
Understanding CGP utilization patterns and their impact on patient outcomes is crucial for optimizing cancer care.

Purpose of the Study:

To evaluate Comprehensive Genomic Profiling (CGP) utilization patterns in adult patients with metastatic solid tumors (MST).
To assess the impact of the timing of CGP on overall survival (OS) in patients with MST.

Main Methods:

Retrospective review of institutional database for CGP data from 01/2012 - 04/2020.
Patients categorized into tertiles based on time from metastatic diagnosis to CGP.
Overall survival (OS) estimated using Cox regression, accounting for time from diagnosis to CGP.

Main Results:

1,358 patients included; common histologies were lung, colorectal, gynecologic, and pancreatic cancers.
CGP timing was equitable across sex and race, with exceptions for Hispanics with lung cancer and females with pancreas cancer.
Early CGP (within the first tertile after diagnosis) correlated with improved survival in lung, gastro-esophageal, and gynecologic cancers.

Conclusions:

Comprehensive Genomic Profiling (CGP) utilization was equitable across demographic groups.
Early CGP after metastatic diagnosis may enhance treatment delivery and clinical outcomes, particularly in cancers with more actionable targets.