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Serum Soluble Intercellular Adhesion Molecule-1 (sICAM-1): A Novel Potential Biomarker in Severe Acne Vulgaris
Amany Ibrahim Mustafa1, Adel Ali Ebrahim1, Waleed Abdel Lateef Abel Halim2
1Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University, Egypt.
Background:
Acne vulgaris (AV) is a chronic inflammatory disorder. Intercellular adhesion molecule-1 (ICAM-1) is a vital adhesion molecule mediating cellular adhesion during the inflammatory process.
Aims And Objectives:
To evaluate serum soluble intercellular adhesion molecule-1 (sICAM-1) level in AV patients as an attempt to elucidate its role in acne pathogenesis and to relate with studied clinical parameters.
Materials And Methods:
Serum sICAM-1 level was measured using ELISA technique in 60 patients and 60 controls.
Results:
Serum sICAM-1 level was significantly elevated in studied patients than controls (P < 0.001). Additionally, its level increased significantly with increased acne severity (P < 0.001) but not in patients with post acne scars (P > 0.05).
Conclusion:
Serum sICAM-1 could be a marker for acne etiopathogenesis. Furthermore, it might be considered as a predictor for disease severity.
