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Published on: October 16, 2021
Congenital Mitral Regurgitation Repair Based on Carpentier's Classification: Long-Term Outcomes
Koji Miwa1, Shigemitsu Iwai1, Tomomitsu Kanaya1
1Department of Cardiovascular Surgery, Osaka Women's and Children's Hospital, Osaka, Japan.
Insights
Pediatric mitral valve repair using Carpentier
Area of Science:
- Pediatric Cardiac Surgery
- Congenital Heart Disease
- Valvular Heart Disease
Background:
- Limited reports exist on standardized surgical management for mitral valve malformations based on Carpentier's classification.
- Congenital mitral regurgitation (CMR) requires tailored surgical approaches.
- Long-term outcomes of pediatric mitral valve repair are crucial for clinical practice.
Purpose of the Study:
- To evaluate the long-term outcomes of mitral valve repair in pediatric patients.
- To analyze repair success rates stratified by Carpentier's classification of mitral valve lesions.
- To assess freedom from mitral valve replacement and reoperation post-repair.
Main Methods:
- Retrospective review of 23 pediatric patients undergoing mitral valve repair (2000-2021).
- Analysis of preoperative data, surgical techniques, and outcomes categorized by Carpentier's classification.
- Kaplan-Meier analysis to estimate freedom from mitral valve replacement and reoperation.
Main Results:
- Follow-up of 10 years (median age 4 months) with no operative mortality.
- Overall 5-year freedom from mitral valve replacement was 91%.
- Five-year freedom from reoperation ranged from 67% (Type 4) to 80% (Type 2) based on Carpentier's classification.
Conclusions:
- Standardized surgical management for congenital mitral regurgitation yields favorable long-term outcomes.
- Complex mitral valve lesions (Carpentier types) may necessitate combined surgical techniques for successful repair.
- Mitral valve repair in children demonstrates good durability, with low rates of reoperation and replacement.
Background:
There are few reports of the outcomes of standardized surgical management addressing the etiologic and morphologic aspects of mitral valve malformation according to Carpentier's classification. This study aimed to evaluate the long-term outcomes of mitral valve repair in children according to Carpentier's classification.
Methods:
Patients who underwent mitral valve repair at our institution between 2000 and 2021 were retrospectively reviewed. Preoperative data, surgical techniques, and outcomes were analyzed according to Carpentier's classification. The proportion of patients free of mitral valve replacement and reoperation was estimated using Kaplan-Meier analysis.
Results:
Twenty-three patients (median operative age, four months) were followed up for 10 (range, 2-21) years. Preoperative mitral regurgitation was severe in 12 patients and moderate in 11 patients. Eight, five, seven, and three patients had Carpentier's type 1, 2, 3, and 4 lesions, respectively. Ventricular septal defect (N = 9) and double outlet of the great arteries from the right ventricle (N = 3) were the most commonly associated cardiac malformations. There were no cases of operative mortality or deaths during the follow-up. The overall five-year rate of freedom from mitral valve replacement was 91%, whereas the five-year rates of freedom from reoperation were 74%, 80%, 71%, and 67% in type 1, 2, 3, and 4 lesions, respectively. Postoperative mitral regurgitation at the last follow-up was moderate in three patients and less than mild in 20 patients.
Conclusions:
Current surgical management of congenital mitral regurgitation is generally considered adequate; however, more complicated cases required a combination of various surgical techniques.
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