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Related Experiment Video

Updated: Aug 8, 2025

Multiparametric Optical Mapping of the Langendorff-perfused Rabbit Heart
09:24

Multiparametric Optical Mapping of the Langendorff-perfused Rabbit Heart

Published on: September 13, 2011

22.7K

Optical mapping of contracting hearts.

Vineesh Kappadan1, Anies Sohi1, Ulrich Parlitz2

  • 1National Heart and Lung Institute (NHLI), Imperial College London, London, UK.

The Journal of Physiology
|March 3, 2023
PubMed
Summary

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Tau20-RETROmapping System Identifies Driver-Like Activation Patterns in Real-Time During Persistent Atrial Fibrillation.

Circulation. Arrhythmia and electrophysiology·2026
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Atrial cardiomyopathy as a multidomain disease: longitudinal evidence for autonomic remodelling.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2026
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Combined emission ratiometry and motion tracking for optical mapping of contracting hearts: Validation with monophasic action potentials.

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Studies in health technology and informatics·2026

Optical mapping visualizes heart electrophysiology. New computer vision and ratiometric techniques enable optical mapping of contracting hearts, overcoming motion artifacts and allowing study of electromechanical interactions.

Area of Science:

  • Cardiovascular Physiology
  • Biomedical Optics
  • Computational Biology

Background:

  • Optical mapping is crucial for studying myocardial electrophysiology in various preparations.
  • Motion artifacts from cardiac contraction pose a significant challenge to optical mapping.
  • Current methods often use uncouplers, preventing electromechanical interaction studies.

Conclusions:

  • Optical mapping of contracting hearts is now feasible due to technological advances.
  • This enables the study of crucial electromechanical interactions and mechano-electric feedback.
  • Further research is needed to refine these techniques for broader application.
Keywords:
action potential durationmotion artifactsmotion trackingoptical mappingratiometryventricular fibrillation

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