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Advanced MR Techniques for Preoperative Glioma Characterization: Part 1.
Lydiane Hirschler1, Nico Sollmann2,3,4, Bárbara Schmitz-Abecassis5,6
1C.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Journal of Magnetic Resonance Imaging : JMRI
|March 3, 2023
Summary
Advanced MRI techniques offer improved glioma assessment beyond conventional methods. This review explores techniques like dynamic contrast-enhanced MRI and diffusion-weighted MRI for better tumor delineation and genotype information.
Area of Science:
- Neuroimaging
- Oncology
- Radiology
Background:
- Conventional structural MRI for gliomas has limitations in delineating diffuse tumors and lacks genotypic information.
- Gliomas are aggressive brain tumors characterized by infiltrative growth, leading to poor patient outcomes.
- Current preoperative MRI protocols need enhancement to address the complexities of glioma assessment.
Purpose of the Study:
- To review the state of the art in advanced MRI techniques for preoperative glioma assessment.
- To evaluate the clinical translation and validation levels of various advanced MRI methods.
- To raise awareness about the potential of novel MRI techniques in neuro-oncology.
Main Methods:
- Review of current literature on advanced MRI techniques for glioma.
- Discussion of dynamic susceptibility contrast (DSC) and dynamic contrast-enhanced (DCE) MRI.
- Exploration of arterial spin labeling (ASL), diffusion-weighted MRI (DWI), vessel imaging, and magnetic resonance fingerprinting (MRF).
Main Results:
- Advanced MRI techniques provide more detailed information than conventional MRI for glioma characterization.
- Specific techniques like DSC-MRI and ASL show promise for assessing tumor vascularity and perfusion.
- DWI aids in evaluating tumor cellularity and microstructure, crucial for diffuse gliomas.
Conclusions:
- Advanced MRI techniques, including DSC-MRI, ASL, and DWI, offer significant advantages over conventional MRI for preoperative glioma assessment.
- Further research and standardization are needed to fully integrate these techniques into routine clinical practice.
- These advanced methods hold the potential to improve tumor delineation, guide treatment decisions, and enhance patient outcomes in glioma management.
