Related Experiment Video
Updated: Aug 16, 2026

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model
Published on: May 21, 2013
Chondroid chordoma
1Department of Pathology, Children's Hospital, Denver, Colorado 80218.
Abstract:
We reject the notion that the concept of "chondroid chordoma" be abandoned in favor of an interpretation of the cartilaginous origin of these lesions. We have demonstrated by electron microscopic and immunohistochemical means that these neoplasms can exhibit distinctly epithelial characteristics in their chondroid as well as their epithelial areas. The presence of desmosomes, cytokeratin, carcinoembryonic, and epithelial membrane antigen in the cells of the chondroid as well as the epithelial areas; the presence of the microtubular inclusions, vimentin, and S-100 protein in the cells of the epithelial as well as chondroid areas; and the intermingling of the two and gradual transitions from one to the other all point to the conclusion that the chondroid and epithelial areas are only differing morphologic expressions of the same entity. The gradual evolution witnessed in the sequential biopsies of this case study, through which a predominantly chondromatous neoplasm became a chordoma of typical histologic appearance, provides further strong evidence to support the contention that chondroid chordoma is a variant of chordoma and not a primary chondrocytic neoplasm.
More Related Videos
06:40Visualization of Chondrocyte Intercalation and Directional Proliferation via Zebrabow Clonal Cell Analysis in the Embryonic Meckel’s Cartilage
Published on: October 21, 2015
08:09Isolation of Chondrocytes and Chondroprogenitors Using Fibronectin Adhesion and Migratory Assay
Published on: October 4, 2024
Related Concept Videos
Growth of Cartilage and Bone Tissue
Compact Bone
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Development of the Limb Synovial Joints
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
Bone Formation by Endochondral Ossification
Degenerative Disc Disease ll: Pathophysiology