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Related Experiment Video

Updated: Aug 8, 2025

Inducement and Evaluation of a Murine Model of Experimental Myopia
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Causal Relationships Between Glycemic Traits and Myopia.

Fen-Fen Li1,2, Meng-Chao Zhu1,2, Yi-Lei Shao1,2

  • 1National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.

Investigative Ophthalmology & Visual Science
|March 3, 2023
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Summary

Low adiponectin and high hemoglobin A1c (HbA1c) levels are linked to increased myopia risk. These findings suggest potential strategies for delaying myopia onset by managing blood glucose through lifestyle choices.

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Area of Science:

  • Ophthalmology
  • Genetics
  • Metabolic Health

Background:

  • The relationship between sugar intake, glycemic control, and myopia risk is not well understood, with conflicting research findings.
  • Existing studies have yielded inconsistent results regarding the influence of glycemic traits on myopia development.

Purpose of the Study:

  • To investigate the association between various glycemic traits and the risk of developing myopia.
  • To clarify the impact of glycemic control on myopia using genetic evidence.

Main Methods:

  • A two-sample Mendelian randomization (MR) design was utilized.
  • Summary statistics from genome-wide association studies were analyzed for six glycemic traits (adiponectin, BMI, fasting glucose, fasting insulin, HbA1c, proinsulin) and myopia.
  • The inverse-variance-weighted (IVW) method and sensitivity analyses were employed.

Main Results:

  • Lower adiponectin levels were consistently associated with a reduced incidence of myopia.
  • Higher hemoglobin A1c (HbA1c) levels were significantly associated with an increased risk of myopia.
  • Sensitivity analyses supported the robustness of these associations.

Conclusions:

  • Genetic evidence indicates that low adiponectin and high HbA1c are risk factors for myopia.
  • Findings suggest that lifestyle factors influencing blood glucose, such as diet and physical activity, may offer strategies for myopia prevention or delay.