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Antidepressant Augmentation versus Switch in Treatment-Resistant Geriatric Depression.

Eric J Lenze1, Benoit H Mulsant1, Steven P Roose1

  • 1From the Department of Psychiatry (E.J.L., P.C., T.R.G., E.L., G.E.N., V.T.P., L.Y.) and the Division of Biostatistics (J.P.M.), Washington University School of Medicine, St. Louis; the Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto (B.H.M., D.M.B., A.J.F.), the Centre for Addiction and Mental Health (B.H.M., D.M.B.), and the Centre for Mental Health, University Health Network (A.J.F.) - all in Toronto; Columbia University College of Physicians and Surgeons and the Department of Psychiatry, New York State Psychiatric Institute - both in New York (S.P.R., P.J.B.); the Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles (H.L., H.A.O.); University of Pittsburgh School of Medicine, Pittsburgh (C.F.R., M.A.G., B.L.R.); and the Department of Psychiatry, College of Medicine, University of Arizona, Tucson (J.F.K.).

The New England Journal of Medicine
|March 3, 2023
PubMed
Summary

Aripiprazole augmentation improved well-being in older adults with treatment-resistant depression more than switching to bupropion. Lithium or nortriptyline provided similar outcomes when initial treatments failed.

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