Related Experiment Video
Updated: Aug 8, 2025

23:33
The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
Published on: February 28, 2012
83.8K
Bexagliflozin: First Approval
1Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand. dru@adis.com.
Drugs
|March 3, 2023
Summary
Bexagliflozin, a sodium-glucose transporter 2 inhibitor, is now approved in the USA for type 2 diabetes management. This oral medication aids glycaemic control alongside diet and exercise.
Area of Science:
- Pharmacology
- Endocrinology
- Cardiology
Background:
- Bexagliflozin (BRENZAVVY™) is an oral sodium-glucose transporter 2 (SGLT-2) inhibitor.
- It is developed by TheracosBio for type 2 diabetes (T2D) and essential hypertension.
Purpose of the Study:
- To summarize development milestones of bexagliflozin.
- To highlight its first US approval for T2D treatment.
Main Methods:
- Review of clinical development data.
- Analysis of regulatory submission and approval process.
Main Results:
- Bexagliflozin received US approval in January 2023.
- Approved as an adjunct to diet and exercise for T2D glycaemic control.
Conclusions:
- Bexagliflozin represents a new therapeutic option for T2D.
- Further development is ongoing for essential hypertension treatment.
Related Concept Videos
Glucagon-like Receptor Agonists
380
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
380
Dipeptidyl Peptidase 4 Inhibitors
224
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
224
Oral Hypoglycemic Agents: Glinides
202
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
202
Oral Hypoglycemic Agents: Biguanides and Glitazones
250
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
250
Oral Hypoglycemic Agents: Sulfonylureas
268
Sulfonylureas are oral hypoglycemic agents utilized in treating type 2 diabetes. They are characterized by their unique sulfonylurea chemical structure. The family of sulfonylureas is divided into generations. First-generation sulfonylureas, including tolbutamide (Orinase), chlorpropamide (Diabinese), and tolazamide (Tolinase), trigger insulin release from pancreatic β cells and enhance peripheral tissues' insulin sensitivity. The second-generation members, such as glipizide...
268
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
228
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
Acarbose and miglitol are...
228

