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Related Experiment Video

Updated: Aug 8, 2025

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
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Carotid stenting: Does stent design matter?

Mohamed Shahat1, Enrico Cieri2, Joao Rocha-Neves3

  • 1Department of Vascular and Endovascular Surgery, Assiut University Hospital, Assiut University, Assiut, Egypt.

Vascular
|March 3, 2023
PubMed
Summary
This summary is machine-generated.

Carotid artery stenting (CAS) is a safe procedure for selected patients. Stent design impacts complications like stroke and hypotension, with open-cell stents showing lower hypotension rates.

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Area of Science:

  • Vascular Surgery
  • Interventional Cardiology
  • Neurology

Background:

  • Carotid artery stenting (CAS) is a key intervention for carotid revascularization.
  • Stent design significantly influences CAS outcomes, including perioperative stroke, hemodynamic instability, and restenosis.

Purpose of the Study:

  • To evaluate the impact of different carotid artery stent designs on clinical outcomes.
  • To analyze complication rates associated with various stent designs in CAS procedures.

Main Methods:

  • Retrospective analysis of 728 consecutive patients undergoing CAS for atherosclerotic carotid stenosis (March 2014-May 2021).
  • Inclusion criteria: symptomatic stenosis ≥50% or asymptomatic stenosis ≥60%. Exclusion criteria: fibromuscular dysplasia, acute/unstable plaque.
  • Multivariable logistic regression analysis was used to identify relevant clinical variables.

Main Results:

  • Successful CAS achieved in 96% of patients; stroke rates were 5.8% (symptomatic) and 3.4% (asymptomatic).
  • Open-cell stents were not linked to increased risk of neurologic complications compared to closed-cell stents.
  • Patients receiving open-cell stents demonstrated significantly lower rates of procedural hypotension (P=0.0188).

Conclusions:

  • CAS is a safe alternative to carotid endarterectomy for select patients.
  • Stent design variations can influence major adverse event rates in CAS.
  • Further unbiased studies are needed to definitively assess the effect of different stent designs on CAS outcomes.