Related Experiment Video
Updated: Aug 8, 2025
06:55
Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
Published on: January 8, 2020
14.5K
One-Year Adverse Outcomes Among US Adults With Post-COVID-19 Condition vs Those Without COVID-19 in a Large
Andrea DeVries1, Sonali Shambhu1, Sue Sloop1
1Elevance Health, Inc, Indianapolis, Indiana.
JAMA Health Forum
|March 3, 2023
Summary
Individuals with post-COVID-19 condition (PCC) face significantly higher risks of adverse cardiovascular and respiratory outcomes, plus increased mortality, one year after initial infection. This highlights the need for ongoing monitoring and specialized care for PCC patients.
Area of Science:
- Medical research
- Epidemiology
- Public health
Background:
- Post-acute sequelae of SARS-CoV-2, or post-COVID-19 condition (PCC), affects many individuals after initial infection.
- Long-term outcomes for individuals with PCC are not well understood.
Purpose of the Study:
- To quantify 1-year outcomes in individuals meeting a PCC definition.
- To compare these outcomes with a control group without COVID-19.
Main Methods:
- A case-control study utilized national insurance claims data, laboratory results, and mortality data.
- A propensity score-matched control group of individuals without COVID-19 was used.
- The study included 13,435 individuals with PCC and 26,870 controls, assessed over 12 months.
Main Results:
- The PCC cohort showed increased healthcare utilization for adverse outcomes, including cardiac arrhythmias (RR, 2.35), pulmonary embolism (RR, 3.64), and ischemic stroke (RR, 2.17).
- Higher risks were also observed for coronary artery disease, heart failure, COPD, and asthma.
- Mortality was higher in the PCC group (2.8%) compared to controls (1.2%).
Conclusions:
- Individuals surviving the acute phase of COVID-19 with PCC face elevated rates of adverse cardiovascular and pulmonary outcomes a year later.
- Findings underscore the necessity for continuous monitoring of at-risk individuals, especially for cardiovascular and pulmonary complications.
More Related Videos
Related Concept Videos
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
153
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
153
01:12Relative Risk
267
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
267
01:17Classification of Illness
7.7K
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
7.7K
01:20Actuarial Approach
106
The actuarial approach, a statistical method originally developed for life insurance risk assessment, is widely used to calculate survival rates in clinical and population studies. This method accounts for participants lost to follow-up or those who die from causes unrelated to the study, ensuring a more accurate representation of survival probabilities.
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
106
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.6K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.6K
01:19Pharmacovigilance
933
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
933