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Related Experiment Video

Updated: Aug 8, 2025

Microfluidics in Assessing Platelet Function
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Patterns of Platelet Mapping Thromboelastography Abnormalities in Trauma.

Seth A Quinn1, Stephen E Gregg1, Nicole Garcia1

  • 1Division of Trauma and Acute Care, Department of Surgery, The Brody School of Medicine, East Carolina University, Greenville, NC, USA.

The American Surgeon
|March 3, 2023
PubMed
Summary

Platelet mapping thromboelastography (TEG-PM) can predict outcomes in trauma patients. Specific TEG-PM abnormalities correlate with increased mortality and longer hospital stays, particularly in TBI patients.

Keywords:
critical caretrauma

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Area of Science:

  • Trauma Care
  • Coagulopathy Research
  • Diagnostic Hemostasis

Background:

  • Trauma-induced coagulopathy is a significant concern in patient outcomes.
  • Platelet mapping thromboelastography (TEG-PM) is increasingly used to assess coagulopathy.
  • Understanding TEG-PM's predictive value in trauma, including TBI, is crucial.

Purpose of the Study:

  • To evaluate the association between TEG-PM parameters and clinical outcomes in trauma patients.
  • To specifically assess these associations in patients with traumatic brain injury (TBI).

Main Methods:

  • Retrospective review of the American College of Surgeons National Trauma Database.
  • Exclusion of patients on anti-platelets, anticoagulation, or who received blood products pre-arrival.
  • Generalized linear models and Cox cause-specific hazards models used to analyze TEG-PM values and outcomes (mortality, LOS).

Main Results:

  • 1066 trauma patients included; 151 with isolated TBI.
  • ADP inhibition linked to increased hospital and ICU length of stay (LOS).
  • Increased maximal amplitude (MA) values correlated with decreased LOS.
  • Elevated R and LY30 values associated with increased in-hospital mortality risk.

Conclusions:

  • Specific TEG-PM abnormalities are significantly associated with adverse outcomes in trauma patients.
  • Findings highlight the prognostic utility of TEG-PM in trauma and TBI.
  • Further research is needed to elucidate the relationship between traumatic injury and coagulopathy.