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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
Published on: January 28, 2014
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BIOMARKERS: CAN THEY REALLY GUIDE OUR DAILY PRACTICE?
Iraklis Tsangaris1, Nikolaos Antonakos2, Massimo Fantoni
12nd Department of Critical Care Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Shock (Augusta, Ga.)
|March 3, 2023
Summary
Accurate sepsis management relies on assessing patient severity and prognosis using biomarkers like suPAR, CRP, ferritin, and procalcitonin. Novel biosensor technology offers noninvasive monitoring for personalized patient care.
Area of Science:
- Critical Care Medicine
- Biomarker Discovery
- Diagnostic Technology
Background:
- Effective management of septic patients necessitates precise evaluation of disease severity and patient prognosis.
- Circulating biomarkers have significantly advanced sepsis assessment since the 1990s.
- Current practices require improved tools for timely and accurate patient stratification.
Purpose of the Study:
- To summarize recent advancements in using biomarkers for sepsis management.
- To explore the role of novel technologies in assessing sepsis severity and prognosis.
- To discuss the potential for personalized medicine in sepsis care.
Main Methods:
- Review of circulating biomarkers including ultrasensitive bacteremia detection, soluble urokinase-type plasminogen activator receptor (suPAR), C-reactive protein (CRP), ferritin, and procalcitonin.
- Evaluation of novel multiwavelength optical biosensor technology for noninvasive metabolite monitoring.
- Discussion of biomarker applications in guiding clinical practice for septic patients.
Main Results:
- Established biomarkers (suPAR, CRP, ferritin, procalcitonin) aid in assessing sepsis severity and prognosis.
- Novel optical biosensor technology shows potential for noninvasive, real-time monitoring of metabolites.
- These advancements collectively enhance the ability to personalize sepsis management strategies.
Conclusions:
- Biomarkers are crucial for optimizing the management of septic patients.
- Advanced biosensor technologies offer promising noninvasive methods for monitoring sepsis.
- Personalized management of sepsis can be significantly improved through the integrated application of biomarkers and new technologies.
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