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Sudden Cardiac Death in Patients With Mitral Valve Prolapse in US (1999-2020)

Marco Zuin1, Gianluca Rigatelli2, Claudio Bilato3

  • 1Department of Cardiology, West Vicenza Hospital, Arzignano, Vicenza, Italy; Department of Translational Medicine, University of Ferrara, Ferrara, Italy.

The American Journal of Cardiology
|March 3, 2023
PubMed

Insights

Sudden cardiac death (SCD) in mitral valve prolapse (MVP) patients is rare but more common in younger White women in urban areas. Identifying risk factors can improve risk stratification for MVP patients.

Area of Science:

  • Cardiology
  • Epidemiology
  • Public Health

Background:

  • Mitral valve prolapse (MVP) is a common valvular heart condition.
  • Data on sudden cardiac death (SCD) incidence in MVP patients is limited.
  • Understanding SCD risk in MVP is crucial for patient management.

Purpose of the Study:

  • To investigate the mortality rate of SCD in US patients with MVP.
  • To identify demographic characteristics associated with SCD in MVP patients.

Main Methods:

  • Analysis of the CDC WONDER Multiple Cause of Death Dataset (1999-2020).
  • Cohort study design.
  • Inclusion of US subjects with MVP who died from SCD.

Main Results:

  • 824 US subjects with MVP died from SCD between 1999-2020, representing 0.3% of all SCDs.
  • Higher SCD mortality rates were observed in women under 44 years old.
  • White ethnicity and urban residency were associated with increased SCD risk.

Conclusions:

  • SCD mortality in MVP patients is low overall but shows specific demographic patterns.
  • Identifying at-risk subgroups can inform targeted risk stratification strategies.
  • Further research into risk factors for SCD in MVP is warranted.

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