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Updated: Aug 8, 2025

Ex vivo Culturing of Whole, Developing Drosophila Brains
Published on: July 27, 2012
Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brain
Carina Seah1, Kristen J Brennand1
1Pamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Departments of Psychiatry and Genetics, Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA.
Abstract:
In this issue, Wells et al. combine genetic multiplexing ("village-in-a-dish") and Stem-cell-derived NGN2-accelerated Progenitors (SNaPs) to evaluate genotype-phenotype relationships across 100 donors in the context of Zika virus infection in the developing brain. This resource will be broadly applicable in uncovering how genetic variation underlies risk for neurodevelopmental disorders.
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