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Physiopathologic changes in lambs fed with Astragalus lusitanicus Lam.
A Garcia Roman1, M R Moyano Salvago, F Soler Rodriguez
1Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Cordoba, Spain.
Veterinary and Human Toxicology
|October 1, 1987
Summary
Acute poisoning in lambs from A lusitanicus Lam caused a nervous syndrome. This condition, a form of locoism, may be linked to a thiamine deficiency in affected animals.
Area of Science:
- Veterinary Toxicology
- Animal Neurology
- Biochemistry
Background:
- Acute experimental poisoning in lambs is a significant concern in animal health.
- Ovine neurological syndromes can arise from various toxic exposures.
- Understanding the pathophysiology of poisoning is crucial for effective treatment.
Purpose of the Study:
- To investigate the effects of acute experimental poisoning with A lusitanicus Lam in lambs.
- To characterize the nervous syndrome and associated physiopathological changes.
- To explore the potential role of thiamine deficiency in the observed 'locoism'.
Main Methods:
- Experimental induction of poisoning in lambs using A lusitanicus Lam.
- Clinical observation for neurological signs.
- Collection and analysis of blood and cerebrospinal fluid samples.
- Assessment of biochemical parameters indicative of nervous system function.
Main Results:
- Lambs exhibited a distinct nervous syndrome following A lusitanicus Lam exposure.
- Physiopathological changes were observed in blood and cerebrospinal fluid.
- These alterations indicated significant nervous system damage.
- The syndrome presented as a form of 'locoism'.
Conclusions:
- A lusitanicus Lam is confirmed as a causative agent of acute poisoning in lambs.
- The poisoning induces a neurological disorder characterized by specific blood and CSF alterations.
- The development of this 'locoism' may be associated with thiamine deficiency, warranting further investigation.