Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
X-Inactivation01:58

X-Inactivation

The human X chromosome contains over ten times the number of genes as in the Y chromosome. Since males have only one X chromosome, and females have two, one might expect females to produce twice as many of the proteins, with undesirable results.
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
X-inactivation01:58

X-inactivation

The human X chromosome contains over ten times the number of genes as in the Y chromosome. Since males have only one X chromosome, and females have two, one might expect females to produce twice as many of the proteins, with undesirable results.
Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond the capsule: an integrated perspective on the wide world of frozen shoulder. A collaborative viewpoint.

Pain management·2026
Same author

Zero Echo Time MRI for Osseous Assessment of Sports-Related Pathology in Athletes: A Pictorial Essay.

Journal of the Belgian Society of Radiology·2026
Same author

Desmoid Tumor of the Abdominal Wall.

Journal of the Belgian Society of Radiology·2026
Same author

How Dark Stars and Three Stripes Can Aid in Characterization of Muscle Sarcoidosis?

Journal of the Belgian Society of Radiology·2025
Same author

The Swollen Finger: Etiology and Imaging Findings.

Seminars in musculoskeletal radiology·2025
Same author

Angioleiomyoma: How to Suggest the Diagnosis on Imaging?

Journal of the Belgian Society of Radiology·2025
Same journal

History of MSK Section of the Italian Society of Radiology.

Seminars in musculoskeletal radiology·2026
Same journal

Principles of Anatomy and Function in Wrist Imaging.

Seminars in musculoskeletal radiology·2026
Same journal

Opportunistic Screening Based on Computed Tomography in Musculoskeletal Radiology: How and Why.

Seminars in musculoskeletal radiology·2026
Same journal

Musculoskeletal Computed Tomography Imaging: A 30-Year Perspective.

Seminars in musculoskeletal radiology·2026
Same journal

Current Advances and Controversies in Spine Imaging.

Seminars in musculoskeletal radiology·2026
Same journal

New Techniques in Musculoskeletal MRI: State of the Art.

Seminars in musculoskeletal radiology·2026
See all related articles

Related Experiment Video

Updated: Jun 27, 2026

Spinal Cord Electrophysiology
04:59

Spinal Cord Electrophysiology

Published on: January 18, 2010

John P. Caffey, 1895-1978.

Peter Beighton1, Filip M Vanhoenacker2,3,4

  • 1Professor Emeritus, Department of Human Genetics, University of Cape Town, South Africa.

Seminars in Musculoskeletal Radiology
|March 3, 2023
PubMed
Summary
This summary is machine-generated.

This article honors Dr. John Caffey, a key figure in pediatric radiology. His work is famously linked to infantile cortical hyperostosis, now called Caffey's disease.

More Related Videos

Multi-Photon Time Lapse Imaging to Visualize Development in Real-time: Visualization of Migrating Neural Crest Cells in Zebrafish Embryos
10:13

Multi-Photon Time Lapse Imaging to Visualize Development in Real-time: Visualization of Migrating Neural Crest Cells in Zebrafish Embryos

Published on: August 9, 2017

Isolation of Adult Human Astrocyte Populations from Fresh-Frozen Cortex Using Fluorescence-Activated Nuclei Sorting
08:18

Isolation of Adult Human Astrocyte Populations from Fresh-Frozen Cortex Using Fluorescence-Activated Nuclei Sorting

Published on: April 16, 2021

Related Experiment Videos

Last Updated: Jun 27, 2026

Spinal Cord Electrophysiology
04:59

Spinal Cord Electrophysiology

Published on: January 18, 2010

Multi-Photon Time Lapse Imaging to Visualize Development in Real-time: Visualization of Migrating Neural Crest Cells in Zebrafish Embryos
10:13

Multi-Photon Time Lapse Imaging to Visualize Development in Real-time: Visualization of Migrating Neural Crest Cells in Zebrafish Embryos

Published on: August 9, 2017

Isolation of Adult Human Astrocyte Populations from Fresh-Frozen Cortex Using Fluorescence-Activated Nuclei Sorting
08:18

Isolation of Adult Human Astrocyte Populations from Fresh-Frozen Cortex Using Fluorescence-Activated Nuclei Sorting

Published on: April 16, 2021

Area of Science:

  • Pediatric Radiology
  • Medical History

Background:

  • The "Leaders in MSK Radiology" series highlights significant contributors.
  • Dr. John Caffey made notable contributions to the field.

Purpose of the Study:

  • To commemorate the achievements of Dr. John Caffey.
  • To discuss his association with infantile cortical hyperostosis.

Main Methods:

  • Historical review of Dr. Caffey's career.
  • Examination of his contributions to radiology and pediatric conditions.

Main Results:

  • Dr. Caffey's name is synonymous with infantile cortical hyperostosis.
  • His work advanced the understanding of this condition.

Conclusions:

  • Dr. Caffey's legacy is cemented through his namesake disease.
  • His impact on musculoskeletal radiology and pediatric diagnosis is significant.