Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pharmacoeconomic analysis of switch to faricimab for neovascular age-related macular degeneration in real clinical practice.

Global & regional health technology assessment·2026

Same author

Non-Myopic Foveomacular Retinoschisis: Stellate Non-Hereditary Idiopathic Foveomacular Retinoschisis (SNIFR) and Central Anomalous Retinoschisis with Mid-Peripheral Traction (CARPET).

Diagnostics (Basel, Switzerland)·2026

Same author

Exploratory study on a novel automatic quantification software by artificial intelligence for geographic atrophy associated to age-related macular degeneration.

International journal of retina and vitreous·2026

Same author

Surgical management of myopic traction maculopathy; expert perspectives from the myopia society.

Progress in retinal and eye research·2026

Same author

Faricimab treat-and-extend approach for neovascular age-related macular degeneration: insights from real-world clinical practice.

International journal of retina and vitreous·2025

Same author

Pharmacoproteomics in the development of personalised medicine in Age-related Macular Degeneration (PHARPRO-AMD) study protocol.

BMJ open ophthalmology·2025

Search research articles

Related Experiment Video

Updated: Aug 8, 2025

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

Posterior Staphyloma as Determining Factor for Myopic Maculopathy.

José M Ruiz-Moreno¹, Mariluz Puertas², Ignacio Flores-Moreno³

¹Puerta de Hierro-Majadahonda University Hospital (J.M.R.-M., M.P., I.F.-M., E.A.-A., M.G-Z., J.R.-M), Madrid, Spain; Department of Ophthalmology (J.M.R.-M.), Castilla La Mancha University, Albacete, Spain; Miranza Corporation (J.M.R.-M., J.R.-M), Madrid, Spain.

American Journal of Ophthalmology

|March 3, 2023

Summary

Posterior staphyloma (PS) is linked to myopic maculopathy and poorer vision. Axial length and age are key factors in developing PS, impacting severe pathologic myopia.

More Related Videos

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Iris Fixation via External Pentagram Suturing

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

Related Experiment Videos

Last Updated: Aug 8, 2025

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Iris Fixation via External Pentagram Suturing

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

Area of Science:

Ophthalmology
Medical Imaging
Retinal Diseases

Background:

High myopia is a significant risk factor for vision-threatening complications.
Posterior staphyloma (PS) is a common finding in highly myopic eyes, but its specific impact on myopic maculopathy requires further elucidation.
Understanding the factors contributing to PS is crucial for predicting and managing severe outcomes in pathologic myopia.

Purpose of the Study:

To investigate the association between posterior staphyloma (PS) and the development of myopic maculopathy.
To identify the key clinical and anatomical factors associated with the presence of PS in highly myopic eyes.

Main Methods:

A cross-sectional study involving 467 highly myopic eyes (axial length [AL] ≥26 mm) from 246 patients.
Ophthalmological examinations and multimodal imaging were performed.
Eyes were analyzed for the presence of PS and compared based on age, AL, best-corrected visual acuity (BCVA), atrophy/traction/neovascularization (ATN) components, and severe pathologic myopia (PM) in age-matched and AL-matched cohorts.

Main Results:

Posterior staphyloma (PS) was present in 69.59% of the eyes studied.
Eyes with PS exhibited significantly higher AL, increased ATN components, a higher prevalence of severe pathologic myopia (PM), and worse best-corrected visual acuity (BCVA) compared to eyes without PS.
Both increasing age and axial length (AL) were identified as significant risk factors for the development of PS, with AL having a more pronounced effect.

Conclusions:

Posterior staphyloma (PS) is strongly associated with the presence of myopic maculopathy and reduced visual acuity.
The development of PS is primarily driven by axial length and age, in that order.
These findings underscore the importance of monitoring PS in highly myopic patients to mitigate risks of severe visual impairment.