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Updated: Aug 8, 2025

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection

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Utilizing a Questionnaire to Implement a Risk-based Antibiotic Prophylaxis Protocol for Transrectal Prostate Biopsy.

Zeynep G Gul¹, Michelle Yu¹, Danielle R Sharbaugh¹

¹Department of Urology, University of Pittsburgh, Pittsburgh, PA.

|March 3, 2023

Summary

This summary is machine-generated.

A new risk-based antibiotic prophylaxis protocol for transrectal prostate biopsies reduced antibiotic use without increasing infection rates. This approach optimizes antibiotic stewardship in urological procedures.

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Area of Science:

Urology
Infectious Diseases
Pharmacology

Background:

Transrectal prostate biopsy is associated with a risk of infectious complications.
Antibiotic prophylaxis is standard practice, but overuse contributes to antimicrobial resistance.

Purpose of the Study:

To develop and evaluate a risk-based antibiotic prophylaxis protocol for patients undergoing transrectal prostate biopsy.
To reduce unnecessary antibiotic exposure while maintaining patient safety.

Main Methods:

A risk-based protocol was implemented, screening patients for infection risk factors via questionnaire.
Antibiotic regimens and 30-day infection rates were compared between a pre-intervention and intervention period.

Main Results:

The percentage of patients receiving augmented prophylaxis decreased significantly (74% to 45%).
Antibiotic duration and dosage also decreased significantly.
Infection rates (5%) and sepsis rates (1-2%) remained unchanged between groups.

Conclusions:

A risk-based antibiotic prophylaxis protocol for transrectal prostate biopsy effectively reduces antibiotic use.
This protocol does not increase infectious complications, supporting its clinical utility and antimicrobial stewardship.