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Changes in medication regimen complexity index following medication-related hospital admissions: A retrospective

Isabelle Gillooly1, Edwin Ck Tan1, Ilsa R Wojt1

  • 1The University of Sydney, Faculty of Medicine and Health, School of Pharmacy, Sydney, Australia.

Research in Social & Administrative Pharmacy : RSAP
|March 4, 2023
PubMed
Abstract

Insights

Medication-related hospitalizations reduce medication regimen complexity. Higher complexity upon admission predicts longer hospital stays, highlighting opportunities for medication reviews to prevent readmissions.

Area of Science:

  • Pharmacology
  • Health Services Research
  • Geriatrics

Background:

  • Medication-related hospitalizations offer chances for de-prescribing and simplifying medication regimens.
  • The Medication Regimen Complexity Index (MRCI) quantifies medication regimen complexity.

Purpose of the Study:

  • To assess changes in MRCI after medication-related hospitalizations.
  • To examine the association between MRCI, length of stay (LOS), and patient characteristics.

Main Methods:

  • Retrospective medical record review of patients hospitalized for medication-related problems in Australia (Jan 2019 - Aug 2020).
  • MRCI calculated using pre-admission and discharge medication lists.

Main Results:

  • Median MRCI decreased post-hospitalization (17.0 to 15.0, p < 0.001) in 125 patients.
  • Admission MRCI predicted LOS ≥2 days (OR 1.03, p=0.022).
  • Allergic reaction hospitalizations linked to lower admission MRCI.

Conclusions:

  • Medication regimen complexity decreases following medication-related hospitalizations.
  • Targeted medication reviews for high-risk patients can reduce post-discharge complexity and prevent readmissions.
Keywords:
Adverse drug eventsAdverse drug reactionsDosing errorsMedication regimen complexityMedication-related hospitalisations

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