[Comparative local and systemic immunization against experimentally-induced Bordetella bronchiseptica pneumonia in...

It is described the experimental Bordetella bronchiseptica infection via aerosol in ICR mice. 10(6) living bacteria were found in the lung after aerosol challenge with a total of 10(12) CFU. The pneumonias produced in this infection model within 10 days are focal, interstitial and proliferative to a low and medium degree, respectively. They are significantly reduced already by a single i.p. or s.c. immunization. Two vaccinations with inactivated Bordetellae or a temperature sensitive mutant reduce the frequency and severity of the pneumonias, dependent on the administered immunizing dose. The efficacy of two consecutive immunizations via aerosol is comparable to that of two i.p. vaccinations.