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The relative strength of an acid or base is the extent to which it ionizes when dissolved in water. If the ionization reaction is essentially complete, the acid or base is termed strong; if relatively little ionization occurs, the acid or base is weak. There are many more weak acids and bases than strong ones. The most common strong acids and bases are listed below:
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CIPDB: A biological structure databank for studying cation and π interactions.

Jing-Fang Yang1, Fan Wang2, Meng-Yao Wang2

  • 1Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, PR China; International Joint Research Center for Intelligent Biosensor Technology and Health, Central China Normal University, Wuhan 430079, PR China; State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China.

Drug Discovery Today
|March 5, 2023
PubMed
Summary

Cation and π interactions are crucial for protein folding and molecular recognition, often outcompeting hydrogen bonds. This review details their identification, characteristics, and biological roles, aiding drug discovery.

Keywords:
biologicalcation-πdatasetdrugfunctionnoncovalent interactionpesticidestructure

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Area of Science:

  • Biochemistry
  • Structural Biology
  • Computational Chemistry

Background:

  • Cation and π interactions are significant forces in protein structures.
  • These interactions play a critical role in molecular recognition, surpassing hydrogen bonds in importance.
  • They are fundamental to numerous biological processes.

Purpose of the Study:

  • To review methods for identifying and quantifying cation and π interactions.
  • To provide insights into the natural characteristics of these interactions.
  • To reveal the biological functions of cation and π interactions and introduce the CIPDB database.

Main Methods:

  • Literature review of cation and π interactions.
  • Analysis of existing data in protein structures.
  • Development and introduction of the Cation and π Interaction in Protein Data Bank (CIPDB).

Main Results:

  • Cation and π interactions are prevalent and competitive in molecular recognition.
  • Established methods for identification and quantification are presented.
  • The biological significance and database (CIPDB) are detailed.

Conclusions:

  • This review provides a foundation for studying cation and π interactions.
  • Understanding these interactions is vital for molecular design in drug discovery.
  • The CIPDB database serves as a valuable resource for researchers.