E26 transformation-specific transcription variant 5 in development and cancer: modification, regulation and function

Area of Science:

• Molecular Biology
• Oncology
• Genetics

Background:

• E26 transformation-specific (ETS) transcription variant 5 (ETV5), also known as ETS-related molecule (ERM), is crucial for normal physiological processes.
• ETV5 is frequently overexpressed in various cancers, acting as an oncogenic transcription factor.
• Dysregulation of ETV5 involves post-translational modifications, gene fusions, signaling crosstalk, and non-coding RNAs.

Purpose of the Study:

• To systematically review the molecular structure, post-translational modifications, and functions of ETV5.
• To summarize the critical roles of ETV5 in both benign and malignant diseases.
• To delineate the molecular mechanisms of ETV5 in cancer biology and tumor progression.

Main Methods:

• Literature review and synthesis of existing research on ETV5.
• Analysis of ETV5's molecular structure and post-translational modifications.
• Compilation of data on ETV5's involvement in various diseases and cancer progression.

Main Results:

• ETV5 is implicated in essential physiological functions like development and metabolism.
• ETV5 overexpression correlates with cancer progression, metastasis, proliferation, and drug resistance.
• ETV5 serves as a potential prognostic biomarker and therapeutic target in oncology.

Conclusions:

• ETV5 exhibits diverse roles in normal physiology and disease, particularly in cancer.
• Understanding ETV5's molecular mechanisms is vital for developing targeted cancer therapies.
• ETV5 holds significant translational potential for clinical applications in oncology.